Safety and Effectiveness of Nustim System Implantation in Dogs
Main Article Content
Keywords
摘要
Objectives: To verify the safety and effectiveness of a novel micro-implantable wireless nerve stimulation device in healthy adult beagles and evaluate the feasibility of using the device in clinical practice.
Methods: The stimulator was experimentally implanted into the quadriceps femoris of three adult beagles. The animals were subjected to training on daily basis for 14 days, and the threshold test was administered once a week. At the end, we analyzed the images of light microscopy and electron microscopy.
Results: The implantation was easy to perform and the whole stimulation system worked stably and reliably. The stimulation threshold was stable. During the process, the stimulator did not move or cause damage to adjacent tissues. The whole system showed a good biocompatibility with recipient animals. The stimulator could induce muscular contraction and enhance the motor function of muscles.
Conclusions: The preliminary results showed that the stimulator could be safely implanted into animal body, with good tissue compatibility, stability and reliability. In addition, it also worked well in eliciting muscle contraction. It promises to be used for the treatment of stress urinary incontinence in future.
##plugins.generic.paperbuzz.metrics##
参考
Grimby A, Milsom I, Molander U, Wiklund I, Ekelund P. The influence of urinary incontinence on the quality of life of elderly women. Age Ageing. 1993;22(2):82-9. Epub 1993/03/01. https://doi.org/10.1093/ageing/22.2.82. PMID: 8470564.
Dumoulin C, Hay-Smith J. Pelvic floor muscle training versus no treatment, or inactive control treatments, for urinary incontinence in women. Cochrane Database Syst Rev. 2010;(1):Cd005654. Epub 2010/01/22. https://doi.org/10.1002/14651858.CD005654.pub2. PMID: 20091581.
Kane MJ, Breen PP, Quondamatteo F, ÓLaighin G. BION microstimulators: a case study in the engineering of an electronic implantable medical device. Med Eng Phys. 2011;33(1):7-16. Epub 2010/11/23. https://doi.org/10.1016/j.medengphy.2010.08.010. PMID: 21087890.
Abrams P, Cardozo L, Fall M, Griffiths D, Rosier P, Ulmsten U, et al. The standardisation of terminology of lower urinary tract function: report from the Standardisation Sub-committee of the International Continence Society. Neurourol Urodyn. 2002;21(2):167-78. Epub 2002/02/22. https://doi.org/10.1002/nau.10052. PMID: 11857671.
Wolin LH. Stress incontinence in young, healthy nulliparous female subjects. J Urol. 1969;101(4):545-9. Epub 1969/04/01. https://doi.org/10.1016/s0022-5347(17)62378-4. PMID: 5776039.
Hannestad YS, Rortveit G, Daltveit AK, Hunskaar S. Are smoking and other lifestyle factors associated with female urinary incontinence? The Norwegian EPINCONT Study. Bjog. 2003;110(3):247-54. Epub 2003/03/12. PMID: 12628262.
Grady D, Brown JS, Vittinghoff E, Applegate W, Varner E, Snyder T. Postmenopausal hormones and incontinence: the Heart and Estrogen/Progestin Replacement Study. Obstet Gynecol. 2001;97(1):116-20. Epub 2001/01/12. https://doi.org/10.1016/s0029-7844(00)01115-7. PMID: 11152919.
Ward KL, Hilton P. A prospective multicenter randomized trial of tension-free vaginal tape and colposuspension for primary urodynamic stress incontinence: two-year follow-up. Am J Obstet Gynecol. 2004;190(2):324-31. Epub 2004/02/26. https://doi.org/10.1016/j.ajog.2003.07.029. PMID: 14981369.
Ward K, Hilton P. Prospective multicentre randomised trial of tension-free vaginal tape and colposuspension as primary treatment for stress incontinence. Bmj. 2002;325(7355):67. Epub 2002/07/13. https://doi.org/10.1136/bmj.325.7355.67. PMID: 12114234; PMCID: PMC117136.
Newman DK. Pelvic floor muscle rehabilitation using biofeedback. Urol Nurs. 2014;34(4):193-202. Epub 2014/09/23. PMID: 25233622.
Dumoulin C, Hay-Smith J, Habée-Séguin GM, Mercier J. Pelvic floor muscle training versus no treatment, or inactive control treatments, for urinary incontinence in women: a short version Cochrane systematic review with meta-analysis. Neurourol Urodyn. 2015;34(4):300-8. Epub 2014/11/20. https://doi.org/10.1002/nau.22700. PMID: 25408383.
Kashanian M, Ali SS, Nazemi M, Bahasadri S. Evaluation of the effect of pelvic floor muscle training (PFMT or Kegel exercise) and assisted pelvic floor muscle training (APFMT) by a resistance device (Kegelmaster device) on the urinary incontinence in women: a randomized trial. Eur J Obstet Gynecol Reprod Biol. 2011;159(1):218-23. Epub 2011/07/12. https://doi.org/10.1016/j.ejogrb.2011.06.037. PMID: 21741151.
Wan X, Liang Y, Li X, Liao L. Inhibitory effects of a minimally invasive implanted tibial nerve stimulation device on non-nociceptive bladder reflexes in cats. Int Urol Nephrol. 2021;53(3):431-8. Epub 2020/09/30. https://doi.org/10.1007/s11255-020-02666-w. PMID: 32989670.