Chinese botulinum toxin A for the treatment of lower urinary tract dysfunction: It works just as well
Main Article Content
Keywords
botulinum neurotoxin type A, Hengli®, lower urinary tract dysfunction, Chinese
Abstract
The botulinum neurotoxin type A (BoNT/A) is a neurotoxin produced by Clostridium botulinum. It causes botulism and represents the most powerful natural poison. In urological practice, the indications for BoNT/A therapy include neurogenic detrusor overactivity (NDO), idiopathic overactive bladder (OAB) or idiopathic detrusor overactivity (IDO), detrusor-sphincter dyssynergia (DSD), interstitial cystitis/bladder pain syndrome (IC/BPS), urinary tract infections (UTI), benign prostatic hyperplasia (BPH), and, more recently, chronic prostatic pain (CPP). BoNT/A is not only conducive to the treatment of muscle spasticity but also effectively works on hyperalgesia associated with various disorders of the lower urinary tract, thanks to its anti-nociceptive properties. While Botox® (Allergan Inc., Irvine, CA) is currently being used across the globe, we have been using Chinese BoNT/A for many years for the treatment of DSD, NDO, idiopathic OAB, IC/BPS, BPH and UTI. Our experience showed that Chinese BoNT/A was as good as other BoNT/A products in terms of efficacy, safety, and tolerability. In this study, we explored the current and potential applications of Chinese BoNT/A in urology, and reviewed the background information regarding the toxin.
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References
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Hill KK, Smith TJ. Genetic diversity within Clostridium botulinum serotypes, botulinum neurotoxin gene clusters and toxin subtypes. Curr Top Microbiol Immunol. 2013;364:1-20. https://doi.org/10.1007/978-3-642-33570-9_1 PMID: 23239346
Nitti VW. Botulinum toxin for the treatment of idiopathic and neurogenic overactive bladder: state of the art. Rev Urol. 2006 Fall;8(4):198-208. PMID: 17192799
Yao G, Lee K, Gu S, Lam KH, Jin R. Botulinum neurotoxin A complex recognizes host carbohydrates through its hemagglutinin component. Toxins (Basel). 2014 Feb 12;6(2):624-35. https://doi.org/10.3390/toxins6020624 PMID: 24525478
Dykstra DD, Sidi AA. Treatment of detrusor-sphincter dyssynergia with botulinum A toxin: a double-blind study. Arch Phys Med Rehabil. 1990 Jan;71(1):24-6. PMID: 2297305
Stohrer M, Schurch B, Kramer G. Botulinum A-toxin in the treatment of detrusor hyperreflexia in spinal cord injured patients: a new alternative to medical and surgical procedures? J Urol. 2000 Sep;164(3 Pt 1):692-7. https://doi.org/10.1097/00005392-200009010-00018 PMID: 10953127
Karsenty G, Denys P, Amarenco G, De Seze M, Gamé X, Haab F, et al. Botulinum toxin A (Botox) intradetrusor injections in adults with neurogenic detrusor overactivity/neurogenic overactive bladder: a systematic literature review. Eur Urol. 2008 Feb;53(2):275-87. https://doi.org/10.1016/j.eururo.2007.10.013 PMID: 17988791
Leippold T, Reitz A, Schurch B. Botulinum toxin as a new therapy option for voiding disorders: current state of the art. Eur Urol. 2003 Aug;44(2):165-74. https://doi.org/10.1016/s0302-2838(03)00250-1 PMID: 12875934
Zhao Y, Wei R, Liu CM, Zhang XP, Feng DJ, Gao XJ, et al. [Cloning and Sequencing of Complete BoNT Gene of Clostridium botulinum Type A for Therapy]. Chin J Biologicals. 2010;23(06):598-601. Chinese. https://doi.org/10.13200/j.cjb.2010.06.43.zhaoyj.010.
Quagliato EM, Carelli EF, Viana MA. Prospective, randomized, double-blind study, comparing botulinum toxins type a botox and prosigne for blepharospasm and hemifacial spasm treatment. Clin Neuropharmacol. 2010 Jan-Feb;33(1):27-31. https://doi.org/10.1097/WNF.0b013e3181c46f61 PMID: 20124784
Rieder CR, Schestatsky P, Socal MP, Monte TL, Fricke D, Costa J, et al. A double-blind, randomized, crossover study of prosigne versus botox in patients with blepharospasm and hemifacial spasm. Clin Neuropharmacol. 2007 Jan-Feb;30(1):39-42. https://doi.org/10.1097/01.Wnf.0000236771.77021.3c PMID: 17272968
He X, Miao CH, Li XJ, Wang YT, Liang Q, Zhang XP, et al. [Biological characteristics and quality of botulinum toxin type A for injection]. Chin J Biologicals. 2012;25(11):1488-91, 97. Chinese. https://doi.org/10.13200/j.cjb.2012.11.89.hex.039.
Inoue K, Fujinaga Y, Watanabe T, Ohyama T, Takeshi K, Moriishi K, et al. Molecular composition of Clostridium botulinum type A progenitor toxins. Infect Immun. 1996;64(5):1589-94. https://doi.org/10.1128/iai.64.5.1589-1594.1996 PMID: 8613365
Liang Q, Chen S, Zhang R, Wei Z, Su J, Zhou Y, et al. [Nonclinical safety evaluation of botulinum toxin type A and botulinum neurotoxin type A]. Chin J Biologicals. 2017;30(07):710-7. Chinese. https://doi.org/10.13200/j.cnki.cjb.001797.
Chapple C, Patel A. Botulinum toxin--new mechanisms, new therapeutic directions? Eur Urol. 2006;49(4):606-8. https://doi.org/10.1016/j.eururo.2006.01.005 PMID: 16457945
Kuo HC. Therapeutic effects of suburothelial injection of botulinum a toxin for neurogenic detrusor overactivity due to chronic cerebrovascular accident and spinal cord lesions. Urology. 2006;67(2):232-6. https://doi.org/ 10.1016/j.urology.2005.08.016 PMID: 16442605
Schulte-Baukloh H, Schobert J, Stolze T, Stürzebecher B, Weiss C, Knispel HH. Efficacy of botulinum-A toxin bladder injections for the treatment of neurogenic detrusor overactivity in multiple sclerosis patients: an objective and subjective analysis. Neurourol Urodyn. 2006;25(2):110-5. https://doi.org/10.1002/nau.20153 PMID: 16470519
Smith CP, Nishiguchi J, O'Leary M, Yoshimura N, Chancellor MB. Single-institution experience in 110 patients with botulinum toxin A injection into bladder or urethra. Urology. 2005;65(1):37-41. https://doi.org/10.1016/j.urology.2004.08.016 PMID: 15667859
Jiang YH, Liao CH, Kuo HC. Current and potential urological applications of botulinum toxin A. Nat Rev Urol. 2015;12(9):519-33. https://doi.org/10.1038/nrurol.2015.193 PMID: 26260879
Liao L, Fu G, Shi WB, Xiong ZS, Ju YH, Wu J, et al. [Botulinum-A toxin injection in urinary sphincter by endoscope to treat detrusor-sphincter dyssynergia in patients with spinal cord injury]. Chin J Spine and Spinal Cord. 2006;(06):409-12. Chinese. https://doi.org/10.3969/j.issn.1004-406X.2006.06.002
Abrams P, Cardozo L, Fall M, Griffiths D, Rosier P, Ulmsten U, et al. The standardisation of terminology in lower urinary tract function: report from the standardisation sub-committee of the International Continence Society. Urology. 2003;61(1):37-49. https://doi.org/10.1016/s0090-4295(02)02243-4 PMID: 12559262
Sahai A, Khan M, Fowler CJ, Dasgupta P. Botulinum toxin for the treatment of lower urinary tract symptoms: a review. Neurourol Urodyn. 2005;24(1):2-12. https://doi.org/10.1002/nau.20090 PMID: 15578628
Schurch B, Schmid DM, Stöhrer M. Treatment of neurogenic incontinence with botulinum toxin A. N Engl J Med. 2000;342(9):665. https://doi.org/ 10.1056/nejm200003023420918 PMID: 10702067
Schurch B, Stöhrer M, Kramer G, Schmid DM, Gaul G, Hauri D. Botulinum-A toxin for treating detrusor hyperreflexia in spinal cord injured patients: a new alternative to anticholinergic drugs? Preliminary results. J Urol. 2000 Sep;164(3 Pt 1):692-7. https://doi.org/10.1097/00005392-200009010-00018 PMID: 10953127
Dickson EC, Shevky R. Botulism. Studies on the manner in which the toxin of clostridium botulinum acts upon the body: I. The effect upon the autonomic nervous system. J Exp Med. 1923 Apr 30;37(5):711-31. https://doi.org/10.1084/jem.37.5.711 PMID: 1986875
Chen G, Liao L. Injections of Botulinum Toxin A into the detrusor to treat neurogenic detrusor overactivity secondary to spinal cord injury. Int Urol Nephrol. 2011 Sep;43(3):655-62. https://doi.org/10.1007/s11255-010-9873-x PMID: 21110094
Li D, Liao L, Xiong ZS, Fu G, Ju YH, Wu J, et al. [Botulinum toxin type A repeated injections into detrusor to treat detrusor hyperreflexia and neurogenic incontinence in spinal cord injury patients: 6 cases report]. Chin J Rehabil Theory Practice. 2005;(11):30-1. Chinese. https://doi.org/ 10.3969/j.issn.1006-9771.2005.11.01229.
Liao L, Li D, Xiong ZS, Han CS, Huang Y, Shi WB. [Botulinum-A toxin injection into detrusor to treat detrusor hyperreflexia and neurogenic incontinence in patients with spinal cord injury]. Chin J Urol. 2004;(09):19-21. Chinese. https://doi.org/10.3760/j:issn:1000-6702.2004.09.006
Liao L, Ju Y, Li D. [Botulinum Toxin－A Injection into Detrusor to Treat Neurogenic Detrusor Overactivity in Patient s with Spinal Cord Injury]. Chin J Rehabil Theory Practice. 2007;(11):1014-6. Chinese. https://doi.org/10.3969/j.issn.1006-9771.2007.11.005
Popat R, Apostolidis A, Kalsi V, Gonzales G, Fowler CJ, Dasgupta P. A comparison between the response of patients with idiopathic detrusor overactivity and neurogenic detrusor overactivity to the first intradetrusor injection of botulinum-A toxin. J Urol. 2005 Sep;174(3):984-9. https://doi.org/10.1097/01.ju.0000169480.43557.31 PMID: 16094019
Rapp DE, Lucioni A, Katz EE, O'Connor RC, Gerber GS, Bales GT. Use of botulinum-A toxin for the treatment of refractory overactive bladder symptoms: an initial experience. Urology. 2004 Jun;63(6):1071-5. https://doi.org/10.1016/j.urology.2004.01.041 PMID: 15183952
Kalsi V, Apostolidis A, Popat R, Gonzales G, Fowler CJ, Dasgupta P. Quality of life changes in patients with neurogenic versus idiopathic detrusor overactivity after intradetrusor injections of botulinum neurotoxin type A and correlations with lower urinary tract symptoms and urodynamic changes. Eur Urol. 2006 Mar;49(3):528-35. https://doi.org/10.1016/j.eururo.2005.12.012 PMID: 16426735
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Sep 14, 2022
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Zhang, F., Liu, Q., Liao, L., Li, X., & Zhang, X. (2022). Chinese botulinum toxin A for the treatment of lower urinary tract dysfunction: It works just as well. Bladder, 9(1), e47. https://doi.org/10.14440/bladder.2022.847
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