Does deep brain stimulation improve Parkinson’s disease-related lower urinary tract symptoms and voiding dysfunction?
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摘要
Parkinson’s disease (PD), caused by degeneration of dopaminergic neurons, leads to motor and autonomic symptoms. A large proportion of PD patients experience lower urinary tract symptoms (LUTS) and voiding dysfunction, associated with poor quality of life. Deep brain stimulation (DBS) is an adjunctive therapy used in combination with medication for Parkinsonian motor symptoms and is currently being explored to treat PD-related LUTS. This review discusses the current literature on the effects of DBS on lower urinary tract function and whether this modality can be used to modulate PD-related LUTS and voiding dysfunction.
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4. Picillo M, Palladino R, Barone P, Erro R, Colosimo C, Marconi R, et al. The PRIAMO study: urinary dysfunction as a marker of disease progression in early Parkinson's disease. Eur J Neurol. 2017;24(6):788-95. Epub 2017/04/21. doi: 10.1111/ene.13290. PubMed PMID: 28425642.
5. Stone E, Coote JH, Lovick TA. Effect of electrical vs. chemical deep brain stimulation at midbrain sites on micturition in anaesthetized rats. Acta Physiol (Oxf). 2015;214(1):135-45. Epub 2015/03/18. doi: 10.1111/apha.12491. PubMed PMID: 25778550.
6. Winge K, Nielsen KK. Bladder dysfunction in advanced Parkinson's disease. Neurourol Urodyn. 2012;31(8):1279-83. Epub 2012/04/11. doi: 10.1002/nau.22237. PubMed PMID: 22488851.
7. Roy HA, Pond D, Roy C, Forrow B, Foltynie T, Zrinzo L, et al. Effects of pedunculopontine nucleus stimulation on human bladder function. Neurourol Urodyn. 2018;37(2):726-34. Epub 2017/06/13. doi: 10.1002/nau.23321. PubMed PMID: 28605052.
8. Dafsari HS, Martinez-Martin P, Rizos A, Trost M, Dos Santos Ghilardi MG, Reddy P, et al. EuroInf 2: Subthalamic stimulation, apomorphine, and levodopa infusion in Parkinson's disease. Mov Disord. 2019;34(3):353-65. Epub 2019/02/06. doi: 10.1002/mds.27626. PubMed PMID: 30719763.
9. Dafsari HS, Reddy P, Herchenbach C, Wawro S, Petry-Schmelzer JN, Visser-Vandewalle V, et al. Beneficial Effects of Bilateral Subthalamic Stimulation on Non-Motor Symptoms in Parkinson's Disease. Brain Stimul. 2016;9(1):78-85. Epub 2015/09/20. doi: 10.1016/j.brs.2015.08.005. PubMed PMID: 26385442.
10. Green AL, Stone E, Sitsapesan H, Turney BW, Coote JH, Aziz TZ, et al. Switching off micturition using deep brain stimulation at midbrain sites. Ann Neurol. 2012;72(1):144-7. Epub 2012/07/26. doi: 10.1002/ana.23571. PubMed PMID: 22829274.
11. Herzog J, Weiss PH, Assmus A, Wefer B, Seif C, Braun PM, et al. Subthalamic stimulation modulates cortical control of urinary bladder in Parkinson's disease. Brain. 2006;129(Pt 12):3366-75. Epub 2006/11/02. doi: 10.1093/brain/awl302. PubMed PMID: 17077105.
12. Kessler TM, Burkhard FC, Z'Brun S, Stibal A, Studer UE, Hess CW, et al. Effect of thalamic deep brain stimulation on lower urinary tract function. Eur Urol. 2008;53(3):607-12. Epub 2007/08/10. doi: 10.1016/j.eururo.2007.07.015. PubMed PMID: 17686571.
13. Mock S, Osborn DJ, Brown ET, Stuart Reynolds W, Turchan M, Pallavaram S, et al. The Impact of Pallidal and Subthalamic Deep Brain Stimulation on Urologic Function in Parkinson's Disease. Neuromodulation. 2016;19(7):717-23. Epub 2016/05/14. doi: 10.1111/ner.12446. PubMed PMID: 27172446; PubMed Central PMCID: PMCPMC5052109.
14. Mordasini L, Kessler TM, Kiss B, Schupbach M, Pollo C, Kaelin-Lang A. Bladder function in patients with dystonia undergoing deep brain stimulation. Parkinsonism Relat Disord. 2014;20(9):1015-7. Epub 2014/07/06. doi: 10.1016/j.parkreldis.2014.05.016. PubMed PMID: 24984838.
15. Seif C, Herzog J, van der Horst C, Schrader B, Volkmann J, Deuschl G, et al. Effect of subthalamic deep brain stimulation on the function of the urinary bladder. Ann Neurol. 2004;55(1):118-20. Epub 2004/01/06. doi: 10.1002/ana.10806. PubMed PMID: 14705120.
16. Stefani A, Lozano AM, Peppe A, Stanzione P, Galati S, Tropepi D, et al. Bilateral deep brain stimulation of the pedunculopontine and subthalamic nuclei in severe Parkinson's disease. Brain. 2007;130(Pt 6):1596-607. Epub 2007/01/26. doi: 10.1093/brain/awl346. PubMed PMID: 17251240.
17. Weaver FM, Follett K, Stern M, Hur K, Harris C, Marks WJ, Jr., et al. Bilateral deep brain stimulation vs best medical therapy for patients with advanced Parkinson disease: a randomized controlled trial. JAMA. 2009;301(1):63-73. Epub 2009/01/08. doi: 10.1001/jama.2008.929. PubMed PMID: 19126811; PubMed Central PMCID: PMCPMC2814800.
18. Williams A, Gill S, Varma T, Jenkinson C, Quinn N, Mitchell R, et al. Deep brain stimulation plus best medical therapy versus best medical therapy alone for advanced Parkinson's disease (PD SURG trial): a randomised, open-label trial. Lancet Neurol. 2010;9(6):581-91. Epub 2010/05/04. doi: 10.1016/S1474-4422(10)70093-4. PubMed PMID: 20434403; PubMed Central PMCID: PMCPMC2874872.
19. Witte LP, Odekerken VJJ, Boel JA, Schuurman PR, Gerbrandy-Schreuders LC, de Bie RMA, et al. Does deep brain stimulation improve lower urinary tract symptoms in Parkinson's disease? Neurourol Urodyn. 2018;37(1):354-9. Epub 2017/05/04. doi: 10.1002/nau.23301. PubMed PMID: 28464331.
20. Yamamoto T, Uchiyama T, Asahina M, Yamanaka Y, Hirano S, Higuchi Y, et al. Urinary symptoms are correlated with quality of life after deep brain stimulation in Parkinson's disease. Brain Behav. 2018;8(12):e01164. Epub 2018/11/20. doi: 10.1002/brb3.1164. PubMed PMID: 30451394; PubMed Central PMCID: PMCPMC6305927.
21. Zong H, Meng F, Zhang Y, Wei G, Zhao H. Clinical study of the effects of deep brain stimulation on urinary dysfunctions in patients with Parkinson's disease. Clin Interv Aging. 2019;14:1159-66. Epub 2019/08/17. doi: 10.2147/CIA.S204368. PubMed PMID: 31417246; PubMed Central PMCID: PMCPMC6599892.
22. Sakakibara R, Panicker J, Finazzi-Agro E, Iacovelli V, Bruschini H, Parkinson's Disease Subcomittee TNPCiTICS. A guideline for the management of bladder dysfunction in Parkinson's disease and other gait disorders. Neurourol Urodyn. 2016;35(5):551-63. Epub 2015/03/27. doi: 10.1002/nau.22764. PubMed PMID: 25810035.
23. Tai C, Wang J, Jin T, Wang P, Kim SG, Roppolo JR, et al. Brain switch for reflex micturition control detected by FMRI in rats. J Neurophysiol. 2009;102(5):2719-30. Epub 2009/09/11. doi: 10.1152/jn.00700.2009. PubMed PMID: 19741099; PubMed Central PMCID: PMCPMC2777821.
24. Magerkurth C, Schnitzer R, Braune S. Symptoms of autonomic failure in Parkinson's disease: prevalence and impact on daily life. Clin Auton Res. 2005;15(2):76-82. Epub 2005/04/19. doi: 10.1007/s10286-005-0253-z. PubMed PMID: 15834763.
25. Stohrer M, Blok B, Castro-Diaz D, Chartier-Kastler E, Del Popolo G, Kramer G, et al. EAU guidelines on neurogenic lower urinary tract dysfunction. Eur Urol. 2009;56(1):81-8. Epub 2009/05/01. doi: 10.1016/j.eururo.2009.04.028. PubMed PMID: 19403235.
26. Vurture G, Peyronnet B, Palma JA, Sussman RD, Malacarne DR, Feigin A, et al. Urodynamic Mechanisms Underlying Overactive Bladder Symptoms in Patients With Parkinson Disease. Int Neurourol J. 2019;23(3):211-8. Epub 2019/10/15. doi: 10.5213/inj.1938086.043. PubMed PMID: 31607100; PubMed Central PMCID: PMCPMC6790817.
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